Tricyclic antidepressants — including amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, and doxepin — have a narrow therapeutic range and significant toxicity risk in overdose. LC-MS/MS testing quantifies parent drugs and their active metabolites.
This test is used for therapeutic drug monitoring in patients on tricyclic therapy, evaluation of suspected tricyclic overdose, and assessment of compliance or drug interactions. Tricyclic toxicity can cause arrhythmias and seizures, making accurate measurement important. Sample type is serum or plasma.
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