Tricyclic antidepressants — including amitriptyline, nortriptyline, imipramine, desipramine, and others — have significant overdose toxicity, with cardiac arrhythmias and seizures as major risks. Confirmation testing definitively identifies which specific tricyclic is present, supporting accurate toxicology management.
This test is used in emergency settings to confirm presumptive screens, evaluate suspected overdose, and provide medico-legal documentation. Sample type is urine or serum depending on the clinical situation.
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