TSI is the autoantibody responsible for Graves disease, the most common cause of hyperthyroidism. By stimulating the TSH receptor, it drives excess thyroid hormone production. Elevated TSI strongly supports a diagnosis of Graves disease and helps distinguish it from other causes of hyperthyroidism.
This test is used to confirm Graves disease when hyperthyroidism is found, evaluate Graves-related eye disease, assess risk of relapse after antithyroid medication, and predict the risk of neonatal hyperthyroidism in pregnant women with a history of Graves. Falling levels during treatment can support decisions about stopping antithyroid medications. Sample type is serum.
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