tet(M) encodes a ribosomal protection protein that prevents tetracycline from binding effectively to bacterial ribosomes. It is widespread in gram-positive bacteria, including streptococci, staphylococci, and enterococci, and is one of the most common tetracycline resistance mechanisms.
Detection of tet(M) in molecular susceptibility testing helps predict tetracycline resistance and guide antibiotic selection. Sample type is typically a culture isolate or direct clinical specimen.
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