Anti-Sm antibodies are one of the most specific autoantibodies for systemic lupus erythematosus, though they are present in only about 20-30% of patients. Their high specificity makes them valuable when present.
This test is part of the standard workup when lupus is suspected, particularly in patients with positive ANA and clinical features consistent with the disease. It is part of the ACR/EULAR diagnostic criteria for lupus and helps distinguish lupus from other connective tissue diseases. Sample type is serum.
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