Rapid plasma reagin (RPR) is the most commonly used non-treponemal antibody test for syphilis. When positive, the reflex titer measures antibody quantity, which is essential for assessing disease activity and monitoring treatment response. Positive screens typically require confirmation with a treponemal-specific test.
This test is used for syphilis screening in sexually active individuals, pregnant women (where screening is routine), patients with possible syphilis symptoms, and as follow-up to monitor treatment response. Falling titers after treatment indicate effective therapy. Sample type is serum.
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