The qnr family of genes encode pentapeptide repeat proteins that protect bacterial DNA gyrase and topoisomerase IV from fluoroquinolone antibiotics. While they generally cause only low-level resistance on their own, they often coexist with other resistance mechanisms and contribute to clinical failure with quinolones.
Detection of qnrA, qnrB, or qnrS in molecular susceptibility testing helps guide antibiotic selection in gram-negative infections and supports infection control. Sample type is typically a culture isolate or direct clinical specimen.
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