Osteocalcin reflects bone formation activity. Levels are elevated in conditions with increased bone turnover — Paget's disease, hyperparathyroidism, certain cancers — and can also be useful for monitoring response to osteoporosis treatment. Anti-resorptive therapies typically lower osteocalcin, while anabolic agents may increase it.
This test is used in evaluation of bone disorders and monitoring of treatment response. It is most useful when interpreted alongside other bone turnover markers and clinical findings. Sample type is serum.
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