About 10-15% of patients with generalized myasthenia gravis have autoantibodies against muscle-specific kinase (MuSK) rather than the more common acetylcholine receptor antibodies. MuSK-positive myasthenia tends to present differently — with prominent bulbar (speech, swallowing) and respiratory weakness — and responds differently to some treatments.
This test is ordered in patients with clinical features of myasthenia gravis but negative acetylcholine receptor antibodies. A positive MuSK antibody confirms the diagnosis and guides treatment selection, since MuSK-positive disease often requires different therapy. Sample type is serum.
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