Methadone is a long-acting opioid used both for chronic pain and for medication-assisted treatment of opioid use disorder. Its primary metabolite EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) is produced by the body — but not by adding methadone to the urine specimen. Testing for both confirms genuine use versus possible specimen tampering.
This test is used in methadone maintenance programs to verify medication compliance, evaluate possible diversion, and provide medico-legal documentation. The presence of EDDP confirms actual methadone ingestion rather than direct addition to urine. Sample type is urine.
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