Lipase is released into the bloodstream when pancreatic cells are injured or inflamed. Compared to amylase, lipase is more specific to the pancreas and remains elevated longer after the onset of pancreatitis, making it a more reliable diagnostic marker.
This test is ordered when patients present with symptoms suggesting pancreatitis — severe upper abdominal pain, nausea, and vomiting — and to monitor known pancreatic disease. Elevated lipase may also occur in pancreatic cancer, gallstones obstructing the pancreatic duct, intestinal obstruction, and certain kidney conditions. The sample is serum; no specific fasting is generally required, though clinicians may advise it.
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