When SPEP shows a possible M-protein, IFE confirms its presence and identifies the specific immunoglobulin heavy chain (IgG, IgA, IgM) and light chain (kappa or lambda) involved. This characterization is central to diagnosing and classifying plasma cell and B-cell disorders.
This test is used to confirm and classify monoclonal gammopathies, monitor patients with multiple myeloma or MGUS, and evaluate suspected light chain amyloidosis. It is typically interpreted alongside SPEP, free light chains, and other markers. Sample type is serum.
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