When urinary protein electrophoresis suggests a monoclonal protein, immunofixation identifies the specific immunoglobulin class and light chain involved. A 24-hour urine collection provides the most accurate quantitative information about urinary monoclonal protein excretion, important for staging and monitoring light chain disorders.
This test is used in workup of multiple myeloma, AL amyloidosis, light chain disease, and certain kidney disorders. It is typically interpreted alongside serum testing for complete characterization of monoclonal gammopathies. Sample type is a 24-hour urine collection.
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