Homocysteine levels are influenced by genetics and by nutritional status — particularly folate, vitamin B12, and vitamin B6, which are required for its metabolism. Elevated levels can occur with deficiency of these vitamins, kidney disease, hypothyroidism, certain medications, and inherited disorders such as homocystinuria.
This test is used to refine cardiovascular risk in patients with personal or family history of early heart disease or stroke, evaluate unexplained thrombosis, screen for B-vitamin deficiency, and diagnose inherited disorders of homocysteine metabolism. Sample type is serum.
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