Free T4 directly measures the unbound, biologically active fraction of thyroxine, avoiding the influence of changes in binding proteins that can confuse total T4 measurements. It is one of the two most commonly ordered thyroid tests, along with TSH.
This test is used to confirm and characterize hypothyroidism and hyperthyroidism, monitor patients on thyroid hormone replacement, assess thyroid function in pregnancy, and evaluate central (pituitary) thyroid disorders. Sample type is serum.
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