Because DHEA-S is produced almost exclusively by the adrenal glands and has stable blood levels throughout the day, it provides a more reliable measure of adrenal androgen production than DHEA itself. Elevated DHEA-S generally points to an adrenal source of excess androgens, while low levels can occur with adrenal insufficiency or hypopituitarism.
This test is used to evaluate hirsutism, acne, and other signs of androgen excess in women — particularly to distinguish adrenal from ovarian sources; investigate suspected adrenal tumors; and assess adrenal function in adrenal insufficiency. It is also used in pediatric workups for adrenal disorders. Sample type is serum.
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