Desipramine is a tricyclic antidepressant used for depression and certain neuropathic pain conditions. Like other tricyclics, it has a narrow therapeutic range and significant toxicity in overdose, including dangerous cardiac arrhythmias. Blood level monitoring helps balance efficacy and safety.
This test is used to confirm therapeutic levels, evaluate suspected toxicity, assess compliance, and guide dose adjustments. Trough samples are typically most informative. Sample type is serum.
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