D-Dimer is released into the bloodstream when fibrin in a clot is broken down. Elevated levels indicate that clots are being formed and dissolved somewhere in the body, but the test is not specific to a particular location or cause.
This test is most useful for ruling out venous thromboembolism in patients with low to intermediate clinical probability — a negative D-Dimer effectively excludes the diagnosis. It is also used to evaluate DIC, monitor anticoagulation in select situations, and assess certain inflammatory and infectious conditions. D-Dimer can be elevated in many non-thrombotic conditions, so positive results require additional testing for confirmation. Sample type is whole blood in a sodium citrate tube.
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