By combining cystatin C with patient demographic data, this test calculates an estimated GFR that does not depend on muscle mass — a major advantage in patients where creatinine-based eGFR can mislead. The most accurate kidney function estimates often come from combining creatinine and cystatin C in a single equation.
This test is used in patients with abnormal muscle mass, elderly patients, children, those with chronic kidney disease where precise staging matters, and when creatinine-based eGFR results conflict with clinical impressions. Sample type is serum.
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