Most copper in the blood is bound to ceruloplasmin. Copper deficiency, though uncommon, can cause anemia, neuropathy, and immune dysfunction; it can occur with bariatric surgery, excessive zinc supplementation, or rare inherited conditions. High copper levels are seen in Wilson disease (an inherited disorder of copper metabolism) and certain inflammatory states.
This test is ordered to evaluate suspected Wilson disease (alongside ceruloplasmin and 24-hour urine copper), investigate unexplained anemia or neuropathy with possible copper deficiency, and monitor patients with malabsorption or on long-term zinc therapy. Sample type is serum or plasma.
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