Clozapine has unique efficacy in treatment-resistant schizophrenia but carries significant risks including agranulocytosis, myocarditis, seizures, and severe metabolic effects. Therapeutic drug monitoring helps balance efficacy with safety, and adequate blood levels are associated with better treatment outcomes.
This test is used to verify therapeutic levels, evaluate suspected toxicity or breakthrough symptoms, guide dose adjustments (particularly after smoking changes, which significantly affect clozapine metabolism), and assess compliance. Sample type is serum or plasma.
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