The OXA family includes broad-spectrum penicillinases (such as OXA-1, OXA-2) and carbapenemases (such as OXA-23 in Acinetobacter baumannii and the intrinsic OXA-51 group). OXA-type carbapenemases are particularly important in Acinetobacter, which can become highly resistant to nearly all beta-lactam antibiotics.
Detection of these genes in molecular susceptibility testing helps characterize resistance mechanisms and guide therapy, particularly in serious Acinetobacter infections requiring specialized antibiotic combinations. Sample type is typically a culture isolate or direct clinical specimen.
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