CTX-M is now the most common ESBL family globally, found primarily in Escherichia coli and Klebsiella species. CTX-M-producing organisms resist most penicillins and cephalosporins, including third-generation agents like ceftriaxone.
Detection of blaCTX-M in molecular susceptibility testing guides use of carbapenems or other effective alternatives and triggers infection control precautions. Sample type is typically a culture isolate or direct clinical specimen.
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