SHV beta-lactamases are commonly found in Klebsiella pneumoniae and other Enterobacterales. Narrow-spectrum SHV variants confer resistance to penicillins, while ESBL variants of SHV also resist cephalosporins. The specific variant present affects which antibiotics will be effective.
Detection of blaSHV in molecular susceptibility testing supports antibiotic selection in serious gram-negative infections. ESBL-producing organisms typically require carbapenems or newer beta-lactamase inhibitor combinations. Sample type is typically a culture isolate or direct clinical specimen.
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