FOX and ACC are plasmid-mediated AmpC enzymes that hydrolyze cephalosporins, including third-generation drugs like ceftriaxone, and cephamycins. They are not inhibited by clavulanate or tazobactam, limiting use of beta-lactam/inhibitor combinations.
Detection of FOX or blaACC in molecular testing identifies organisms requiring carbapenems or newer agents like cefepime-zidebactam for effective treatment. Sample type is typically a culture isolate or direct clinical specimen.
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