TEM is one of the oldest and most widespread beta-lactamase families. TEM-1 confers resistance to ampicillin and amoxicillin, while ESBL variants of TEM also resist third-generation cephalosporins, significantly limiting treatment options.
Detection of blaTEM is part of comprehensive molecular susceptibility testing in gram-negative infections. Knowing whether TEM is present — and which variant — guides empiric and definitive antibiotic selection. Sample type is typically a culture isolate or direct specimen.
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