blaMOX is a plasmid-mediated AmpC beta-lactamase that hydrolyzes cephalosporins including third-generation drugs. Like other AmpC enzymes, it is not inhibited by clavulanate or tazobactam, limiting use of beta-lactam/inhibitor combinations.
Detection of blaMOX in molecular testing identifies organisms requiring carbapenems or newer combinations for effective treatment. Sample type is typically a culture isolate or direct clinical specimen.