blaFOX is a plasmid-mediated AmpC beta-lactamase that hydrolyzes cephalosporins, including third-generation drugs and cephamycins like cefoxitin. It resists common beta-lactamase inhibitors, limiting treatment options.
Detection of blaFOX in molecular testing identifies organisms requiring carbapenems or newer beta-lactam/inhibitor combinations for effective treatment. Sample type is typically a culture isolate or direct clinical specimen.