blaCMY is the most prevalent plasmid-mediated AmpC beta-lactamase, particularly in E. coli and Salmonella; blaLAT is a related enzyme. Both hydrolyze cephalosporins including third-generation agents like ceftriaxone, and are not inhibited by common beta-lactamase inhibitors.
Detection of these genes in molecular susceptibility testing identifies cephalosporin-resistant infections requiring carbapenems or newer agents. Sample type is typically a culture isolate or direct clinical specimen.
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