Anti-CCP antibodies target citrullinated proteins and are far more specific for rheumatoid arthritis than rheumatoid factor. They often appear before symptoms and can predict more aggressive disease, making early detection clinically valuable. Combined IgG and IgA testing further increases diagnostic sensitivity, particularly in early disease.
This test is ordered to evaluate patients with joint pain, stiffness, and swelling suggestive of inflammatory arthritis. A positive result strongly supports a diagnosis of rheumatoid arthritis and helps distinguish it from other forms of arthritis. Sample type is serum.
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