When the screening ANA is positive, the lab automatically performs an 11-biomarker panel including dsDNA, RNP, Sm, SS-A, SS-B, Scl-70, Chromatin, Jo-1, Centromere B, Sm/RNP, and Ribosomal P antibodies. This comprehensive evaluation helps identify the specific autoimmune disease — lupus, scleroderma, Sjögren syndrome, mixed connective tissue disease, polymyositis, and others.
This reflex approach is used when comprehensive autoimmune workup is needed in patients with positive ANA screens, multi-system inflammatory symptoms, or clinical suspicion of connective tissue disease. The single-draw approach saves time and avoids repeat phlebotomy. Sample type is serum.
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