Myasthenia gravis is an autoimmune disorder in which antibodies attack the acetylcholine receptors at the junction between nerves and muscles, causing muscle weakness that worsens with activity. Acetylcholine receptor binding antibodies are present in the majority of patients with generalized myasthenia gravis.
This test is ordered to evaluate patients with characteristic symptoms such as drooping eyelids, double vision, difficulty swallowing, slurred speech, and fluctuating muscle weakness. A positive result strongly supports the diagnosis. In seronegative cases, additional antibodies such as MuSK or LRP4 may be tested. Sample type is serum.
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