Msr(A) is an ATP-binding cassette (ABC-F) protein that protects ribosomes by removing macrolide and streptogramin B antibiotics from their binding sites. It is found in staphylococci and other gram-positive organisms, conferring resistance to azithromycin, clarithromycin, erythromycin, and similar antibiotics.
Detection of msr(A) in molecular susceptibility testing helps predict failure of macrolide therapy and guides selection of alternative antibiotics for gram-positive infections. Sample type is typically a culture isolate or direct clinical specimen.