These methyltransferase enzymes alter the bacterial ribosome at adenine 2058 of 23S rRNA, preventing antibiotics like azithromycin, clarithromycin, and clindamycin from binding effectively. The erm gene family is common in staphylococci, streptococci, and other gram-positive organisms.
Detection of erm(A), erm(B), or erm(C) in molecular susceptibility testing helps guide antibiotic selection and predicts likely failure of macrolide and lincosamide therapy. It is particularly important when treating respiratory, skin, or invasive gram-positive infections. Sample type is typically a culture isolate or direct clinical specimen.
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